Chondroprotective Effects of Intra-Articular Autologous Conditioned Serum (ACS) Injection: A Human Literature Review
نویسندگان
چکیده
Background and purpose Autologous conditioned serum (ACS) is a disease-modifying drug for treatment of osteoarthritis (OA). To establish that the autologous serum has protective effect on chondropathy. The aim of this study was evaluate the efficacy of ACS as osteoarthritis therapy. Methods Literature review for intraarticular ACS somministration in human study. Results and interpretation We analyzed five major work to evaluate the effectiveness of the ACS. The use of ACS, in articulation patologies, has been reported as a new treatment for chondropathy. The ACS have biochemical and biomechanical properties able to alleviating suffering cartilage. They contain components such as growth factors that have an reparative effect on cartilage. Conclusions Through different clinical trials has been demonstrated variable efficacy. Among several studies there were differences also in the process of preparation and use of autologous serum.
منابع مشابه
Autologous conditioned serum (Orthokine) is an effective treatment for knee osteoarthritis.
OBJECTIVE Osteoarthritis (OA) is prevalent and difficult to treat. Autologous conditioned serum (ACS), marketed under the trade name Orthokine, is a novel, injectable antiarthritic derived from the patient's own blood. The present study is the first time ACS has undergone a controlled clinical trial. METHOD We investigated 376 patients with knee OA in a prospective, randomized, patient- and o...
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INTRODUCTION Intraarticular administration of autologous conditioned serum (ACS) recently demonstrated some clinical effectiveness in treatment of osteoarthritis (OA). The current study aims to evaluate the in vitro effects of ACS on cartilage proteoglycan (PG) metabolism, its composition and the effects on synovial fluid (SF) cytokine levels following intraarticular ACS administration. METHO...
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1] on the paper [2] we published in a previous issue of Arthritis Research & Th erapy. To dispel any concerns about the proper use of the product, the autologous conditioned serum (ACS) in this study was prepared in a GMP (good manufacturing practice) facility in strict accordance with the guidelines supplied by the manufacturer (Orthogen, Düsseldorf, Germany) and was injected six times at 3-da...
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